Longevity Interventions Database

Know of a longevity intervention that should be in our database? Tell us about it and we'll research and add it!

🏆 Overall Evidence Ranking (0-100 points)

This green score combines multiple evidence factors into a comprehensive ranking.

1. Evidence Quality (35 points max)

Based on average study quality scores:


                        Score = (Average Study Quality / 100) × 35 points

Example: If average study quality is 80/100, this contributes (80/100) × 35 = 28 points

2. Study Diversity & Quality (20 points max)

Rewards diverse, high-quality evidence:

Human study ratio: (Human studies / Total extracted studies) × 8 points
RCT ratio: (RCT studies / Total extracted studies) × 6 points
Extraction coverage: (Extracted studies / Total studies) × 3 points
High-quality ratio: (High-quality studies / Total extracted studies) × 3 points


                        Max Score = 8 + 6 + 3 + 3 = 20 points

3. Volume of Evidence (15 points max)

Points awarded based on total number of studies:

Study Count	Points
≥50 studies	15 points
20-49 studies	13 points
10-19 studies	10 points
5-9 studies	7 points
3-4 studies	4 points
2 studies	2 points
1 study	1 point

4. Effect Size (20 points max)

Based on maximum reported lifespan extension:

Lifespan Extension	Points
≥100%	20 points
50-99%	18 points
25-49%	15 points
15-24%	12 points
10-14%	8 points
5-9%	5 points
<5%	2 points

5. Citation Impact (10 points max)

Based on average citations per study:

Average Citations	Points
≥500	10 points
100-499	8 points
50-99	6 points
20-49	4 points
5-19	2 points

Total Possible: 100 points
35 (Quality) + 20 (Diversity) + 15 (Volume) + 20 (Effect) + 10 (Citations)

💙 Individual Study Quality Score (0-100 points)

This blue score assesses the methodological rigor of each individual study.

1. Study Design Type (25 points max)

Study Type	Points
Meta-analysis	25 points
Systematic review	22 points
Randomized controlled trial (RCT)	20 points
Observational/Cohort	15 points
Animal study	12 points
Case-control	10 points
Cross-sectional	8 points
In vitro (cell studies)	5 points
Case series/study	3-4 points

2. Subject Type (20 points max)

Subject Type	Points
Human	20 points
Primate	16 points
Mammal (dog, mouse, rat)	12 points
Other vertebrate	8 points
Invertebrate (worm, fly)	6 points
Cell culture	3 points

3. Sample Size (15 points max)

Points scale with participant count:

Participants	Points
≥5,000	15 points
1,000-4,999	13 points
500-999	11 points
100-499	9 points
50-99	7 points
20-49	5 points
10-19	3 points
<10	1 point

4. Study Methodology (40 points max)

Randomized: +10 points
Placebo-controlled: +10 points
Double-blinded: +10 points
Peer-reviewed: +5 points
Follow-up data: +5 points

Studies gain points for each applicable methodology feature.

Total Possible: 100 points
25 (Design) + 20 (Subject) + 15 (Sample) + 40 (Methodology)

🎯 Confidence Level Classification

Interventions are classified into confidence tiers based on evidence quality:

🟢 HIGH CONFIDENCE

Requires ALL of:

≥3 human studies
≥2 RCTs
Avg quality ≥70/100

🟡 MEDIUM CONFIDENCE

Requires ONE of:

≥2 human studies + ≥1 RCT
≥1 human study + quality ≥50
≥5 total studies

🔴 LOW CONFIDENCE

Criteria:

Limited human data
Mostly animal studies
<3 total studies

⚠️ Important Disclaimers

Automated Analysis: Scores are calculated using AI analysis of published research and may contain errors
Not Medical Advice: This information is for research purposes only - always consult qualified healthcare professionals
Individual Variation: Results from studies may not apply to all individuals
Ongoing Research: Longevity science is rapidly evolving - scores may change as new studies are published
Original Sources: Always review linked original research papers for complete context

Data Sources: PubMed, peer-reviewed journals, clinical trial databases. AI Analysis: Perplexity AI (Sonar model) for cost-effective, high-quality extraction. Updates: Database updated monthly with new research.

Longevity Interventions Database

📝 Suggest New Intervention

🔑 Admin Access

Add New Intervention

🧬 Add New Protocol

📋 Review Study Suggestions

🔗 Link Study to Interventions

🔬 Search PubMed for New Studies

📊 How We Calculate Scores & Rankings